CIPLUKAN’S ANTI-INFLAMMATORY EFFECTS: MECHANISMS UNCOVERED

Authors

  • Yacobus Christian Prasetyo Department of Pharmacology, Faculty of Medicine, Universitas Kristen Duta Wacana, Yogyakarta, Indonesia
  • Noerlina Purwanti Master Programme of Biomedical Science, Faculty of Medicine, Nursing, and Public Health, Universitas Gadjah Mada, Yogyakarta, Indonesia

DOI:

https://doi.org/10.21460/bikdw.v9i1.656

Keywords:

ciplukan, anti-inflammatory effect, immune signaling pathways

Abstract

Background: Ciplukan (Physalis angulata Linn) is a native American plant widely distributed in tropical regions including Indonesia. This herb has been used as a traditional ingredient to treat inflammation as well as other diseases. Ciplukan’s anti-inflammatory effects are thought to be triggered by the active compounds in the various parts of the herb. Objective: This review aims to describe the herb’s anti-inflammatory effects and its mechanisms. Methods: PubMed and Google Scholar databases were searched for articles using Boolean operations with keywords related to Physalis angulata and inflammatory components. We included literature in English and Indonesian without limiting the publication time range. Results: Ciplukan has an anti-inflammatory effect by regulating inflammatory mediators, inhibiting immune signaling pathways, and the genes associated with the immune system.

References

Latifah N, Hidayati AA, Yunas SR, Sulistyorini E. Ciplukan (Physalis angulata L.) [Internet]. Cancer Chemoprevention Research Center, UGM. 2008 [cited 2022 Jun 4]. Available from: https://ccrc.farmasi.ugm.ac.id/?page_id=193

Setiawan SRD. Cara Menanam Tanaman Buah Ciplukan Penuh Khasiat untuk Kesehatan [Internet]. kompas.com. 2021 [cited 2023 Aug 25]. Available from: https://www.kompas.com/ homey/read/2021/10/15/075400476/cara-menanam-tanaman-buah-ciplukan-penuh-khasiat-untuk-kesehatan? page=all

Sun L, Liu J, Liu P, Yu Y, Ma L, Hu L. Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways. Process Biochemistry. 2011 Feb;46(2):482–8.

Soares MBP, Bellintani MC, Ribeiro IM, Tomassini TCB, Ribeiro dos Santos R. Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. Eur J Pharmacol [Internet]. 2003 Jan 10 [cited 2022 Jun 3];459(1):107–12. Available from: https://pubmed.ncbi.nlm.nih.gov/12505539/

do Espírito Santo RF, Lima M da S, Juiz PJL, Opretzka LCF, Nogueira RC, Ribeiro IM, et al. Physalis angulata concentrated ethanolic extract suppresses nociception and inflammation by modulating cytokines and prostanoids pathways. Nat Prod Res [Internet]. 2021 [cited 2022 Jun 3];35(22):4675–9. Available from: https://pubmed.ncbi.nlm.nih.gov/31872780/

Almeida Junior LD, Quaglio AEV, de Almeida Costa CAR, di Stasi LC. Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation. World J Gastroenterol [Internet]. 2017 Jun 28 [cited 2022 Jun 5];23(24):4369–80. Available from: https://www.wjgnet.com/1007-9327/full/v23/i24/4369.htm

Bastos GNT, Silveira AJA, Salgado CG, Picanço-Diniz DLW, do Nascimento JLM. Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways. J Ethnopharmacol [Internet]. 2008 Jul 23 [cited 2022 Jun 3];118(2):246–51. Available from: https://pubmed.ncbi.nlm. nih.gov/18513903/

Pinto NB, Morais TC, Carvalho KMB, Silva CR, Andrade GM, Brito GAC, et al. Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice. Phytomedicine [Internet]. 2010 [cited 2022 Jun 3];17(10):740–3. Available from: https://pubmed.ncbi.nlm. nih.gov/20149612/

Pinto LA, Meira CS, Villarreal CF, Vannier-Santos MA, de Souza CVC, Ribeiro IM, et al. Physalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy. Biomedicine and Pharmacotherapy. 2016 Apr 1;79:129–34.

Dewi S, Isbagio H, Purwaningsih EH, Kertia N, Setiabudy R, Setiati S. A Double-blind, Randomized Controlled Trial of Ciplukan (Physalis angulata Linn) Extract on Skin Fibrosis, Inflammatory, Immunology, and Fibrosis Biomarkers in Scleroderma Patients. Acta Med Indones [Internet]. 2019 Oct;51(4):303–10. Available from: http://www.ncbi.nlm. nih.gov/pubmed/32041913

Vieira AT, Pinho V, Lepsch LB, Scavone C, Ribeiro IM, Tomassini T, et al. Mechanisms of the anti-inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury. Br J Pharmacol [Internet]. 2005 [cited 2022 Jun 3];146(2):244–51. Available from: https://pubmed.ncbi.nlm.nih.gov/16025143/

Lin YH, Hsiao YH, Ng KL, Kuo YH, Lim YP, Hsieh WT. Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity. Toxicol Appl Pharmacol [Internet]. 2020 Sep 1 [cited 2022 Jun 3];402. Available from: https://pubmed.ncbi.nlm.nih.gov/32634518/

Tuan Anh H le, le Ba V, Do TT, Phan VK, Pham Thi HY, Bach LG, et al. Bioactive compounds from Physalis angulata and their anti-inflammatory and cytotoxic activities. J Asian Nat Prod Res [Internet]. 2021 [cited 2022 Jun 3];23(8):809–17. Available from: https://pubmed.ncbi.nlm.nih.gov/33030034/

Sun CP, Qiu CY, Yuan T, Nie XF, Sun HX, Zhang Q, et al. Antiproliferative and Anti-inflammatory Withanolides from Physalis angulata. J Nat Prod [Internet]. 2016 Jun 24 [cited 2022 Jun 3];79(6):1586–97. Available from: https://pubmed.ncbi.nlm.nih.gov/27295506/

Sun CP, Oppong MB, Zhao F, Chen LX, Qiu F. Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential. Org Biomol Chem. 2017 Oct 25;15(41):8700–4.

Sun CP, Qiu CY, Yuan T, Nie XF, Sun HX, Zhang Q, et al. Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities. Sci Rep. 2017;7(1):4057.

Daltro SRT, Santos IP, Barros PL, Moreira DRM, Tomassini TCB, Ribeiro IM, et al. In vitro and In Vivo Immunomodulatory Activity of Physalis angulata Concentrated Ethanolic Extract. Planta Med [Internet]. 2021 Feb 1 [cited 2022 Jun 3];87(1–02):160–8. Available from: https://pubmed.ncbi.nlm.nih.gov/ 32937664/

da Silva Lima M, Evangelista AF, dos Santos GGL, Ribeiro IM, Tomassini TCB, Pereira Soares MB, et al. Antinociceptive properties of physalins from Physalis angulata. J Nat Prod [Internet]. 2014 Nov 14 [cited 2022 Jun 3];77(11):2397–403. Available from: https://pubmed.ncbi.nlm.nih.gov/25396337/

Wang L, Lu S, Wang L, Xin M, Xu Y, Wang G, et al. Anti-inflammatory effects of three withanolides isolated from Physalis angulata L. in LPS-activated RAW 264.7 cells through blocking NF-?B signaling pathway. J Ethnopharmacol. 2021 Aug 10;276:114186.

Yang YJ, Yi L, Wang Q, Xie BB, Dong Y, Sha CW. Anti-inflammatory effects of physalin E from Physalis angulata on lipopolysaccharide-stimulated RAW 264.7 cells through inhibition of NF-?B pathway. Immunopharmacol Immunotoxicol [Internet]. 2017 Mar 4 [cited 2022 Jun 3];39(2):74–9. Available from: https://pubmed.ncbi. nlm.nih.gov/28152630/

Kurniasih W, Yuniaswan AP. Potensi Physalis Angulata (Ciplukan) sebagai Manajemen Kelainan pada Kulit. Jurnal Klinik dan Riset Kesehatan [Internet]. 2022 Feb 4;1(2):87–100. Available from: http://jk-risk.org/index.php/jk-risk/article/ view/13

Suciady M, Meiliana, Hendryanti DN. Studi Literatur: Potensi Tanaman Herbal Indonesia sebagai Imunostimulan dan Anti-stress untuk Pencegahan Covid-19 Berbasis Evidence-based Analysis. Praxis?: Jurnal Sains, Teknologi, Masyarakat dan Jejaring. 2021;4(1).

Sun L, Liu J, Cui D, Li J, Yu Y, Lei M, et al. Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. J Cell Biochem [Internet]. 2010 Feb 15 [cited 2022 Jun 3];109(3):532–41. Available from: https://pubmed.ncbi.nlm.nih.gov/19950196/

Soares MBP, Brustolim D, Santos LA, Bellintani MC, Paiva FP, Ribeiro YM, et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. Int Immunopharmacol [Internet]. 2006 Mar [cited 2022 Jun 3];6(3):408–14. Available from: https://pubmed.ncbi.nlm.nih.gov/16428076/

Sun L, Zhou L, Chen M, Zhong R, Liu J. Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice. J Cell Biochem [Internet]. 2011 Sep [cited 2022 Jun 3];112(9):2376–82. Available from: https://pubmed.ncbi. nlm.nih.gov/21520246/

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Published

2024-06-30

Issue

Vol. 9 No. 1 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA

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Review

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