DEVELOPMENT OF STANDARDIZED OLFACTORY TEST AS A COGNITIVE IMPAIRMENT SCREENING TOOL IN INDONESIAN ELDERLY: A PRELIMINARY STUDY

Authors

  • Kevin Kristian Department of Public Health and Nutrition, School of Medicine and Health Science, Atma Jaya Catholic University, Jakarta, Indonesia
  • Yvonne Suzy Handajani Center of Health Research, Atma Jaya Catholic University, Jakarta, Indonesia
  • Nelly Tina Widjaja Center of Health Research, Atma Jaya Catholic University, Jakarta, Indonesia
  • Ika Suswanti School of Medicine and Health Science, Atma Jaya Catholic University, Jakarta, Indonesia
  • Yuda Turana Atma Jaya Neuroscience and Cognitive Centre, Department of Neurology, Atma Jaya Catholic University, Jakarta, Indonesia

DOI:

https://doi.org/10.21460/bikdw.v9i1.631

Keywords:

neurodegenerative diseases, cognitive impairment, elderly, olfactory function, screening tool, scents

Abstract

The decline of olfactory function is an early indicator of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. An olfactory function assessment instrument using ten familiar scents with multiple-choice answers has been developed, but several items were inapplicable and had not been standardized. This study aimed to identify various scents that have not been standardized for the aging population with normal cognitive function. This research was a preliminary study with a descriptive cross-sectional approach conducted in Kalianyar village, Jakarta, involving 23 elderly participants with normal cognitive function. An instrument consisting of a list of scents was employed in two steps, with or without assistance. Initially, participants had one chance to smell and try to guess the type of scent given. If the scent was not guessed correctly, participants were then provided with multiple-choice options as a hint. Based on the assessment of twelve scents from the existing research, only nine scents were recognizable. Among them, coffee, lemongrass, oranges, eucalyptus, and menthol were the scents with the most correct answers without assistance. Additionally, there were four scents recognized with or without assistance, such as jasmine, lemon, aromatic ginger, and lime. This study found that only nine scents were familiar and had the potential to be utilized in the future as a screening tool for cognitive impairment.

References

Marin C, Vilas D, Langdon C, Alobid I, López-Chacón M, Haehner A, et al. Olfactory Dysfunction in Neurodegenerative Diseases. Curr Allergy Asthma Rep. 2018 Aug 15;18(8):42.

Dan X, Wechter N, Gray S, Mohanty JG, Croteau DL, Bohr VA. Olfactory dysfunction in aging and neurodegenerative diseases. Ageing Res Rev. 2021 Sep;70:101416.

Voznessenskaya V V., Klyuchnikova MA, Rodionova EI, Laktionova TK, Kvasha IG, Klinov AB, et al. A Standardized Test for Evaluation of Olfactory Function for the Russian Population. Biology Bulletin. 2018 Sep 5;45(5):485–9.

Cha H, Kim S, Son Y. Associations Between Cognitive Function, Depression, and Olfactory Function in Elderly People With Dementia in Korea. Front Aging Neurosci. 2022 Jan 11;13.

Luhur JJ, Mirsha, Handajani YS, Turana Y. Determinasi aroma yang familiar sebagai standar pemeriksaan fungsi olfaktori pada lansia di Jakarta. Neurona. 2012;29(3).

Winchester RL, Martyn K. Could Early Identification of Changes in Olfactory Function Be an Indicator of Preclinical Neurodegenerative Disease? A Systematic Review. Neurol Ther. 2020 Dec 11;9(2):243–63.

Citralestari AE, Widayanti JR, Widjaja NT, Turana Y. Variabilitas jawaban responden lansia kognisi normal terhadap uji fungsi olfaktori. Damianus J Med. 2014;13(1):27–32

Turana Y, Lipnicki DM, Handajani YS, Sani TP, Widayanti JR, Suswanti I, et al. Factors associated with odour identification in older Indonesian and white Australian adults. Aging Clin Exp Res. 2020 Feb;32(2):215–21.

Wartono M, Herkutanto H, Lestari N. High toluene exposure risk increases risk of olfactory dysfunction in furniture workers. Universa Medicina. 2016 Feb 26;34(1):68.

Reese E, Kimbrough RD. Acute toxicity of gasoline and some additives. Environ Health Perspect. 1993 Dec;101(suppl 6):115–31.

Mmehibe F, Alagwu D, Ezekwe A, Nwankwo A, Alagwu E. Study Effect of Camphor fumes on the Pulmonary Functions [Internet]. Vol. 6, UK Journal of Pharmaceutical and Biosciences. 2018. Available from: www.ukjpb.com

United Nations. World Population Prospects 2022 [Internet]. 2022. [cited 2023 Dec 14]. Available from: https://desapublications.un.org/file/989/download

Badan Pusat Statistik. Statistik penduduk lanjut usia 2022 [Internet]. 2022. [cited 2023 Dec 14]. Available from: https://www.bps.go.id/id/publication/2022/12/27/3752f1d1d9b41aa69be4c65c/statistik-penduduk-lanjut-usia-2022.html

Pinkhasov RM, Shteynshlyuger A, Hakimian P, Lindsay GK, Samadi DB, Shabsigh R. Are men shortchanged on health? Perspective on life expectancy, morbidity, and mortality in men and women in the United States. Int J Clin Pract. 2010 Mar;64(4):465–74.

Castro JB, Ramanathan A, Chennubhotla CS. Categorical Dimensions of Human Odor Descriptor Space Revealed by Non-Negative Matrix Factorization. PLoS One. 2013 Sep 18;8(9):e73289.

Khamsi R. A fragrance to remember. Nature. 2022;606:52–4.

Wilson RS, Arnold SE, Schneider JA, Tang Y, Bennett DA. The relationship between cerebral Alzheimer’s disease pathology and odour identification in old age. J Neurol Neurosurg Psychiatry. 2007 Jan 1;78(1):30–5.

Backman MLL. Age-related Differences in Episodic Odour Recognition: The Role of Access to Specific Odour Names. Memory. 1997 May;5(3):361–78.

Sai-Guan L, Husain S, Zahedi FD, Ahmad N, Gendeh BS. Cultural Adaptation of Sniffin’ Sticks Smell Identification Test: The Malaysian Version. Iran J Otorhinolaryngol. 2020 Jul;32(111):213–22.

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Published

2024-08-30

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