IMPACT OF SURGICAL APPROACH (ANTERIOR VS POSTERIOR) ON OUTCOMES IN CERVICAL SPONDYLOTIC MYELOPATHY: A META-ANALYSIS

Authors

  • Muhammad Deni Nasution Universitas Sumatera Utara, Indonesia
  • Moriko Madadoni Sebayang Universitas Sumatera Utara, Indonesia
  • Muhammad Rafif Ginting Universitas Sumatera Utara, Indonesia

DOI:

https://doi.org/10.21460/bikdw.v10i2.1255

Keywords:

anterior cervical discectomy, cervical spondylotic myelopathy, posterior decompression, meta-analysis

Abstract

Cervical spondylotic myelopathy (CSM) is the leading cause of non-traumatic spinal cord dysfunction in older adults. Surgical decompression is the standard treatment for moderate to severe cases, but the optimal approach anterior versus posterior remains debated, particularly in multilevel disease. To compare the clinical outcomes of anterior and posterior surgical approaches in the treatment of multilevel cervical spondylotic myelopathy through a systematic review and meta-analysis of recent studies.A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted for comparative studies published between January 2020 and October 2025. Eligible studies compared anterior cervical discectomy and fusion (ACDF) to posterior decompression (laminoplasty or laminectomy with/without fusion) for multilevel CSM. Primary outcomes were Japanese Orthopaedic Association (JOA) score, complication rates, revision surgery and length of stay. Meta-analysis was conducted using RevMan 5.4. Seven studies (n = 12,810 patients) met the inclusion criteria. There was no significant difference in neurological recovery between anterior and posterior approaches (mean difference in JOA score = 0.29, 95% CI: –0.10 to 0.69; p = 0.15; I² = 0%). The anterior group showed a non-significant trend toward fewer complications (RR = 0.67, 95% CI: 0.38–1.20; p = 0.18; I² = 52%) but had a significantly lower revision surgery rate (RR = 0.46, 95% CI: 0.39–0.54; p < 0.00001; I² = 0%). Anterior surgery was also associated with a shorter hospital stay (mean difference = –2.02 days, 95% CI: –2.37 to –1.67; p < 0.00001; I² = 49%). In patients with multilevel CSM, anterior approaches particularly ACDF provide comparable neurological recovery but result in lower revision rates and shorter hospitalization compared to posterior approaches. While anterior surgery may be preferred when anatomically feasible, surgical decisions should remain patient-specific based on alignment, pathology, and comorbidities.

 

References

1. Nouri A, Tetreault L, Singh A, Karadimas SK, Fehlings MG. Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis. Spine (Phila Pa 1976). 2015;40(12):E675-E693. doi:10.1097/BRS.0000000000000913

2. Karadimas SK, Erwin WM, Ely CG, Dettori JR, Fehlings MG. Pathophysiology and natural history of cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2013;38(22 Suppl 1):S21-S36. doi:10.1097/BRS.0b013e3182a7f2c3

3. Mattei TA, Goulart CR, Milano JB, Dutra LP, Fasset DR. Cervical spondylotic myelopathy: pathophysiology, diagnosis, and surgical techniques. ISRN Neurol. 2011;2011:463729. doi:10.5402/2011/463729

4. Bakhsheshian J, Mehta VA, Liu JC. Current Diagnosis and Management of Cervical Spondylotic Myelopathy. Global Spine J. 2017;7(6):572-586. doi:10.1177/2192568217699208

5. Fehlings MG, Barry S, Kopjar B, et al. Anterior versus posterior surgical approaches to treat cervical spondylotic myelopathy: outcomes of the prospective multicenter AOSpine North America CSM study in 264 patients. Spine (Phila Pa 1976). 2013;38(26):2247-2252. doi:10.1097/BRS.0000000000000047

6. Zhang L, Chen J, Cao C, et al. Anterior versus posterior approach for the therapy of multilevel cervical spondylotic myelopathy: a meta-analysis and systematic review. Arch Orthop Trauma Surg. 2019;139(6):735-742. doi:10.1007/s00402-018-03102-6

7. Luo J, Cao K, Huang S, et al. Comparison of anterior approach versus posterior approach for the treatment of multilevel cervical spondylotic myelopathy. Eur Spine J. 2015;24(8):1621-1630. doi:10.1007/s00586-015-3911-4

8. Lee JJ, Lee N, Oh SH, et al. Clinical and radiological outcomes of multilevel cervical laminoplasty versus three-level anterior cervical discectomy and fusion in patients with cervical spondylotic myelopathy. Quant Imaging Med Surg. 2020;10(11):2112-2124. doi:10.21037/qims-20-220

9. Wang B, Lü G, Kuang L. Anterior cervical discectomy and fusion with stand-alone anchored cages versus posterior laminectomy and fusion for four-level cervical spondylotic myelopathy: a retrospective study with 2-year follow-up. BMC Musculoskelet Disord. 2018;19(1):216. Published 2018 Jul 12. doi:10.1186/s12891-018-2136-1

10. Zhai JL, Guo SG, Nie L, Hu JH. Comparison of the anterior and posterior approach in treating four-level cervical spondylotic myelopathy. Chin Med J (Engl). 2020;133(23):2816-2821. doi:10.1097/CM9.0000000000001146

11. Ahmed, O.E.F., Galal, A. Multiple level anterior cervical discectomy and fusion versus posterior laminectomy for the management of multilevel cervical spondylotic myelopathy: clinical and radiological outcome. Egypt J Neurol Psychiatry Neurosurg 56, 32 (2020). https://doi.org/10.1186/s41983-020-00162-7

12. Nunna RS, Khalid S, Chiu RG, et al. Anterior vs Posterior Approach in Multilevel Cervical Spondylotic Myelopathy: A Nationwide Propensity-Matched Analysis of Complications, Outcomes, and Narcotic Use. Int J Spine Surg. 2022;16(1):88-94. doi:10.14444/8198

13. Wilkerson CG, Sherrod BA, Alvi MA, et al. Differences in Patient-Reported Outcomes Between Anterior and Posterior Approaches for Treatment of Cervical Spondylotic Myelopathy: A Quality Outcomes Database Analysis. World Neurosurg. 2022;160:e436-e441. doi:10.1016/j.wneu.2022.01.049

14. Ambati VS, Macki M, Chan AK, et al. Three-level ACDF versus 3-level laminectomy and fusion: are there differences in outcomes? An analysis of the Quality Outcomes Database cervical spondylotic myelopathy cohort. Neurosurg Focus. 2023;55(3):E2. doi:10.3171/2023.6.FOCUS23295

15. Yeh KT, Chen IH, Lee RP, et al. Two surgical strategies for treating multilevel cervical spondylotic myelopathy combined with kyphotic deformity. Medicine (Baltimore). 2020;99(7):e19215. doi:10.1097/MD.0000000000019215

16. Gore DR. Roentgenographic findings in the cervical spine in asymptomatic persons: a ten-year follow-up. Spine (Phila Pa 1976). 2001;26(22):2463-2466. doi:10.1097/00007632-200111150-00013

17. Du W, Wang HX, Lv J, et al. Cervical alignment and clinical outcome of anterior cervical discectomy and fusion vs. anterior cervical corpectomy and fusion in local kyphotic cervical spondylotic myelopathy. Heliyon. 2023;9(8):e19106. Published 2023 Aug 14. doi:10.1016/j.heliyon.2023.e19106

18. Heller JG, Edwards CC 2nd, Murakami H, Rodts GE. Laminoplasty versus laminectomy and fusion for multilevel cervical myelopathy: an independent matched cohort analysis. Spine (Phila Pa 1976). 2001;26(12):1330-1336. doi:10.1097/00007632-200106150-00013

19. Cheung JP, Luk KD. Complications of Anterior and Posterior Cervical Spine Surgery. Asian Spine J. 2016;10(2):385-400. doi:10.4184/asj.2016.10.2.385

20. Chen TP, Qian LG, Jiao JB, et al. Anterior decompression and fusion versus laminoplasty for cervical myelopathy due to ossification of posterior longitudinal ligament: A meta-analysis. Medicine (Baltimore). 2019;98(1):e13382. doi:10.1097/MD.0000000000013382

21. Yamamoto T, Nagoshi N, Yamane J, et al. Prospective Comparison of Posterior Decompression and ACDF for 1-2-Level Degenerative Cervical Myelopathy. Spine (Phila Pa 1976). Published online September 3, 2025. doi:10.1097/BRS.0000000000005491

Downloads

Published

2026-02-09

Citation Check