A REVIEW OF KOMBUCHA ANTIOXIDANT EFFECTS ON ATHEROSCLEROSIS IN PRECLINICAL STUDIES

Authors

  • Elizabeth Pharmacology Department, Medical Faculty of Maranatha Christian University Bandung, Indonesia
  • Sharone Amabel Medical Faculty of Maranatha Christian University Bandung, Indonesia
  • Ardo Sanjaya Anatomy Department, Medical Faculty of Maranatha Christian University Bandung, Indonesia
  • Julia Windi Gunadi Physiology Department, Medical Faculty of Maranatha Christian University Bandung, Indonesia
  • Diana Krisanti Jasaputra Pharmacology Department, Medical Faculty of Maranatha Christian University Bandung, Indonesia

DOI:

https://doi.org/10.21460/bikdw.v8i2.521

Keywords:

kombucha, atherosclerosis, antioxidant, polyphenol

Abstract

Background Atherosclerosis is the leading cause of death among cardiovascular diseases in Indonesia, in which death is possible if uncontrolled. The prevalence of the disease may be prevented by consuming foods or drinks containing high levels of antioxidant such as kombucha. Exploration of kombucha properties as an antioxidant that will improve atherosclerosis could be obtained from preclinical studies. Objective To discuss the antioxidant effect of kombucha on atherosclerosis in preclinical studies. Method This study is a narrative review with literatures from 2013 to 2022. Result Kombucha is an antioxidant-rich beverage made from enzymes generated by the SCOBY bacteria, which are fermented in sweet tea for 7-14 days to achieve optimal quantities of polyphenols. In addition to the antioxidants in the blood, the effect will lower the levels of LDL, VLDL, triglycerides, and total cholesterol in the blood. Moreover, it can increase HDL in blood and inhibit lesion forming in the aorta. Conclusion Polyphenol in kombucha tea has an antiatherogenic effect that may prevent atherosclerosis in preclinical studies. Keywords: antioxidant, atherosclerosis, kombucha, polyphenol

References

Arifin H, Chou K-R, Ibrahim K, Fitri SUR, Pradipta RO, Rias YA, et al. Analysis of Modifiable, Non-Modifiable, and Physiological Risk Factors of Non-Communicable Diseases in Indonesia: Evidence from the 2018 Indonesian Basic Health Research. J Multidiscip Healthc [Internet]. 2022 Sep;Volume 15:2203–21. Available from: https://www.dovepress.com/analysis-of-modifiable-non-modifiable-and-physiological-risk-factors-o-peer-reviewed-fulltext-article-JMDH

Pahwa R, Jialal I. Atherosclerosis. StatPearls. 2021.

Zhou DD, Luo M, Shang A, Mao QQ, Li BY, Gan RY, et al. Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies. Zhang G, editor. Oxidative Medicine and Cellular Longevity. 2021 Jan 28;2021:1–17.

Bishop P, Pitts ER, Budner D, Thompson-Witrick KA. Kombucha: Biochemical and microbiological impacts on the chemical and flavor profile. Food Chemistry Advances. 2022 Oct;1:100025.

Jakubczyk K, Ka?du?ska J, Kochman J, Janda K. Chemical Profile and Antioxidant Activity of the Kombucha Beverage Derived from White, Green, Black and Red Tea. Antioxidants. 2020 May 22;9(5):447.

Li S, Zhang Y, Gao J, Li T, Li H, Mastroyannis A, et al. Effect of Fermentation Time on Physiochemical Properties of Kombucha Produced from Different Teas and Fruits: Comparative Study. J Food Qual. 2022;2022.

Cardoso RR, Moreira L de PD, de Campos Costa MA, Toledo RCL, Grancieri M, Nascimento TP do, et al. Kombuchas from green and black teas reduce oxidative stress, liver steatosis and inflammation, and improve glucose metabolism in Wistar rats fed a high-fat high-fructose diet. Food Funct. 2021;12(21):10813–27.

Tanticharakunsiri W, Mangmool S, Wongsariya K, Ochaikul D. Characteristics and upregulation of antioxidant enzymes of kitchen mint and oolong tea kombucha beverages. J Food Biochem. 2021 Jan 29;45(1).

Aryal S, Baniya MK, Danekhu K, Kunwar P, Gurung R, Koirala N. Total Phenolic Content, Flavonoid Content and Antioxidant Potential of Wild Vegetables from Western Nepal. Plants. 2019 Apr 11;8(4):96.

Watawana MI, Jayawardena N, Ranasinghe SJ, Waisundara VY. Evaluation of the Stability of the Total Antioxidant Capacity, Polyphenol Contents, and Starch Hydrolase Inhibitory Activities of Kombucha Teas Using an In Vitro Model of Digestion. J Chem. 2015;2015:1–9.

Tan WC, Muhialdin BJ, Meor Hussin AS. Influence of Storage Conditions on the Quality, Metabolites, and Biological Activity of Soursop (Annona muricata. L.) Kombucha. Front Microbiol. 2020 Dec 4;11.

Bhattacharya S, Gachhui R, Sil PC. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food and Chemical Toxicology. 2013 Oct;60:328–40.

Bellassoued K, Ghrab F, Makni-Ayadi F, Pelt J Van, Elfeki A, Ammar E. Protective effect of kombucha on rats fed a hypercholesterolemic diet is mediated by its antioxidant activity. Pharm Biol. 2015 Nov 2;53(11):1699–709.

Lobo RO, Shenoy CK. Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats. J Food Sci Technol. 2015 Jul 2;52(7):4491–8.

Alaei Z, Doudi M, Setorki M. The protective role of Kombucha extract on the normal intestinal microflora, high-cholesterol diet caused hypercholesterolemia, and histological structures changes in New Zealand white rabbits. Avicenna J Phytomed. 2020;10(6):604–14.

Liu L, Nagai I, Gao Y, Matsushima Y, Kawai Y, Sayama K. Effects of catechins and caffeine on the development of atherosclerosis in mice. Bioscience, 9. Aryal S, Baniya MK, Danekhu K, Kunwar P, Gurung R, Koirala N. Total Phenolic Content, Flavonoid Content and Antioxidant Potential of Wild Vegetables from Western Nepal. Plants. 2019 Apr 11;8(4):96.

Watawana MI, Jayawardena N, Ranasinghe SJ, Waisundara VY. Evaluation of the Stability of the Total Antioxidant Capacity, Polyphenol Contents, and Starch Hydrolase Inhibitory Activities of Kombucha Teas Using an In Vitro Model of Digestion. J Chem. 2015;2015:1–9.

Tan WC, Muhialdin BJ, Meor Hussin AS. Influence of Storage Conditions on the Quality, Metabolites, and Biological Activity of Soursop (Annona muricata. L.) Kombucha. Front Microbiol. 2020 Dec 4;11.

Bhattacharya S, Gachhui R, Sil PC. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food and Chemical Toxicology. 2013 Oct;60:328–40.

Bellassoued K, Ghrab F, Makni-Ayadi F, Pelt J Van, Elfeki A, Ammar E. Protective effect of kombucha on rats fed a hypercholesterolemic diet is mediated by its antioxidant activity. Pharm Biol. 2015 Nov 2;53(11):1699–709.

Lobo RO, Shenoy CK. Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats. J Food Sci Technol. 2015 Jul 2;52(7):4491–8.

Alaei Z, Doudi M, Setorki M. The protective role of Kombucha extract on the normal intestinal microflora, high-cholesterol diet caused hypercholesterolemia, and histological structures changes in New Zealand white rabbits. Avicenna J Phytomed. 2020;10(6):604–14.

Liu L, Nagai I, Gao Y, Matsushima Y, Kawai Y, Sayama K. Effects of catechins and caffeine on the development of atherosclerosis in mice. Bioscience, Biotechnology, and Biochemistry. 2017 Oct 3;81(10):1948–55.

Mika M, Kostogrys RB, Franczyk-?arów M, Wikiera A, Ma?lak E. Anti-atherosclerotic activity of catechins depends on their stereoisomerism. Atherosclerosis. 2015 May;240(1):125–30.

Mangge H. Antioxidants, inflammation and cardiovascular disease. World J Cardiol [Internet]. 2014;6(6):462. Available from: http://www.wjgnet.com/1949-8462/full/v6/i6/462.htm

Downloads

Published

2024-01-31

Citation Check