The Effect of Body Mass Index on Five Years Progression Free Survival in Breast Cancer

Authors

  • Wiwiek Probowati internal medicine department of bethesda hospital Yogyakarta, Duta Wacana Christian University, Indonesia
  • Tejo Jayadi pathological anatomy department of bethesda hospital, Duta Wacana Christian University, Indonesia
  • brenda miriane rustam Duta Wacana Christian University, Indonesia
  • agatha maheswari adita putri Duta Wacana Christian University, Indonesia

DOI:

https://doi.org/10.21460/bikdw.v7i2.473

Keywords:

BMI, breast cancer, progression free survival

Abstract

Backgroud Breast cancer is the type of cancer that has the highest prevalence. Breast cancer growth is related to nutritional status. Nutritional status is assessed based on measurements of BMI Body Mass Index (BMI) and obesity is a factor that plays a role in the growth of cancer cells.Objective To investigate the effect of BMI on the five-year progression-free survival (PFS) of breast cancer patientsMethods A retrospective cohort study using observational methods on 82 female patients with breast cancer at Bethesda Hospital, Yogyakarta.Results A total of 82 medical records of breast cancer patients were collected at Bethesda Hospital Yogyakarta. A total of 71 patients (86.6%) were still alive, while 11 have died. This study found an average progression-free survival of BMI category <25 kg/m2 78,5 months while the BMI ≥ 25.0 kg/m² 80,9 months (HR 2,057, 95% CI: .457–2.491). In addition, BMI and other prognostic variables did not have a significant relationship with progression-free survival in breast cancer patients (p = 0.114).Conclusion In this study, Body Mass Index was not associated with the 5-year progression-free survival of breast cancer patients. 

References

Ayuza M, Harahap WA, Rustam R, Nindrea RD. Faktor yang Berpengaruh Terhadap Disease Free Survival dan Overall Survival pada Pasien Kanker Payudara Usia Muda di Kota Padang Tahun 2008 - 2018. J Kesehat Andalas. 2020;9(1S):65–73.

Safarudin, Prihartono NA, Gautama W. Pengaruh Indeks Massa Tubuh terhadap Kanker Payudara di Rumah Sakit Kanker Disease-Free Survival Lima Tahun Pasien “Dharmais†Jakarta. Indones J Cancer. 2016;10(1):19–28.

Kementerian Kesehatan RI. Panduan Pelaksanaan Gerakan Nusantara Tekan Angka Obesitas (GENTAS). Jakarta; 2017. 1–41 p.

Saleh K, Carton M, Dieras V, Heudel PE, Brain E, D’Hondt V, et al. Impact of body mass index on overall survival in patients with metastatic breast cancer. Breast. 2021;55:16–24.

Sun L, Zhu Y, Qian Q, Tang L. Body mass index and prognosis of breast cancer. Medicine (Baltimore). 2018;97(26(e11220)).

Turkoz FP, Solak M, Petekkaya I, Keskin O, Kertmen N, Sarici F, et al. The prognostic impact of obesity on molecular subtypes of breast cancer in premenopausal women. J BUON. 2013;18(2):335–41.

Cihan YB. Relationship of body mass index with prognosis in breast cancer patients treated with adjuvant radiotherapy and chemotherapy. Asian Pacific J Cancer Prev. 2014;15(10):4233–8.

Al Jarroudi O, Abda N, Seddik Y, Brahmi SA, Afqir S. Overweight: Is it a prognostic factor in women with triple-negative breast cancer? Asian Pacific J Cancer Prev. 2017;18(6):1519–23.

Chan D.S.M., Vieira A.R., Aune D., Bandera E.V., Greenwood D.C., McTiernan A., et al. Body mass index and survival in women with breast cancer – systematic literature review and meta-analysis of 82 follow-up studies. Annals of Oncology 25: 1901-14.

Iyengar N.M., Gulcap A., Dannenberg A.J., Hudis C.A. Obesity and Cancer Mechanism: Tumor Microenvironment and Inflammation. Journal of Clinical Incology 34 (35): 4270-77.

Downloads

Published

2022-12-20

Citation Check