Vitamin D Status In Epileptic Adults With Valproic Acid Therapy At The Neurology Clinic, Diponegoro National Hospital, Semarang

Santoso Jaeri, Adelia Putri Maharani1, Dwi Ngestiningsih, Arinta Puspita Wati3, Hasna Syariva

Abstract


Background Epilepsy is a brain disease characterized by repeated unprovoked seizures at least two times with an interval of more than 24 hours between the first seizure and subsequent seizures. Valproic acid is an anti-seizure drug. Long-term use of valproic acid may be associated with metabolic disorders such as weight gain, and lipid profile changes, including vitamin D levels.

Objectives To determine the correlation between the duration of valproic acid therapy and serum vitamin D levels in adults using valproic acid.

Methods An observational analytic study with a cross-sectional design. The demographic and duration of valproic acid use were determined using questioner, and the serum vitamin D levels were measured using the ELISA method. The normality test was carried out using the Shapiro-Wilk test and then continued with the Pearson test to determine the correlation between the duration of valproic acid therapy and serum vitamin D levels. The results showed significance if the p-value <0.05.

Results The mean serum vitamin D level among subjects was low (16.44+4,24 ng/mL), furthermore, there is no significant correlation between the duration of valproic acid therapy and serum vitamin D levels (p=0.956, r=-0,011).

Conclusion There is vitamin D deficiency among adults with epilepsy but, the duration of valproic acid therapy does not correlate with serum vitamin D levels.


Keywords


Epilepsy, antiepileptic, valproic acid, vitamin D

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References


Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82. doi: 10.1111/epi.12550.

Tedyanto EH, Chandra L, Adam OM. Gambaran Penggunaan Obat Anti Epilepsi ( OAE ) pada Penderita Epilepsi Berdasarkan Tipe Kejang di Poli Saraf Rumkital DR. Ramelan Surabaya. Vol. 2071, Jurnal Ilmiah Kedokteran Wijaya Kusuma. 2020;2071. 77–84. doi:10.30742/jikw.v9i1.748.

Nanau RM, Neuman MG. Adverse drug reactions induced by valproic acid. Clin Biochem.2013;46(15):1323-38. doi: 10.1016/j.clinbiochem.2013.06.012.

Tantri NL, Nur FT, Salimo H. Pengaruh Pemberian Obat Antiepilepsi terhadap Kadar Vitamin D pada Anak Penderita Epilepsi. Sari Pediatr. 2017;19(2):97-101.

Pajanan Sinar Ultraviolet B Bersumber dari Sinar Matahari terhadap Konsentrasi Vitamin D (25(OH)D) dan Hormon Paratiroit pada Perempuan Usia Lanjut Indonesia. Kesmas Natl Public Heal J. 2008;2(4):147.

Wheeler BJ, Snoddy AME, Munns C, Simm P, Siafarikas A, Jefferies C. A Brief History of Nutritional Rickets. Front Endocrinol 2019;10:79

doi:10.3389/fendo.2019.00795.

Pitetzis DA, Spilioti MG, Yovos JG, Yavropoulou MP. The effect of VPA on bone: From clinical studies to cell cultures-The molecular mechanisms revisited. Seizure. 2017 May;48:36- 43. doi: 10.1016/j.seizure.2017.03.013.

Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin North Am. 2010 Jun;39(2):243-53. doi: 10.1016/j.ecl.2010.02.002.

Kusumastuti K, Jaeri S. The effect of long-term valproic acid treatment in the level of total cholesterol among adult. Indian J Pharmacol. 2020;52(2):134-137. doi:10.4103/ijp.IJP_655_18.

Prawitasari D, Niken O. Korelasi antara durasi dan dosis obat anti epilepsi generasi pertama (monoterapi) terhadap kadar vitamin D dan kalsium serum pasien epilepsi dewasa. Doctoral dissertation,Universitas Hasanuddin; 2020.

Batubara RS. Hubungan Pemberian Obat Antiepilepsi dengan Vitamin D pada Penderita Epilepsi [Internet]. Universitas Sumatera Utara. 2019. Available from: http://repositori.usu.ac.id/handle/123456789/22 839.

Xu Z, Jing X, Li G, Sun J, Guo H, Hu Y, et al. Valproate decreases vitamin D levels in pediatric patients with epilepsy. Seizure. 2019;71:60–5. doi

:10.1016/j.seizure.2019.06.009.

Abdullah AT, Mousheer ZT. Vitamin D Status in Epileptic Children on Valproic Acid; a Case- Control Study. Arch Acad Emerg Med. 2020;8(1):1–5.

Ningsih SU, Octaviana F, Soertidewi L, Budikayanti A, Prihartono J. Gambaran kadar vitamin D pada penggunaan obat antiepilepsi generasi pertama. Neurona. 2013;30(4):1–4.

Haneef Z, Jacobson M. Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone. Neurology. 2007;68(22):1958-9. doi: 10.1212/01.wnl.0000265361.28780.5f.




DOI: http://dx.doi.org/10.21460/bikdw.v6i2.431

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